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Linder, 34, received the life-changing gift of a kidney from his wife, Emily, in September He will be on immunosuppressants for the rest of his life to keep his body from rejecting the organ. In March , as Covid cases started to shut down workplaces and cities , Emily moved in with her parents for months because she works with the homeless and people in the prison system and did not want to get her husband sick.

The coronavirus vaccines brought some hope for the Linders, who live in Akron, Ohio. Andrew Linder had two doses of the Pfizer vaccine and later an additional dose and a booster. Hope quickly turned to heartbreak. Linder is one of many moderately to severely immunocompromised people trying to protect themselves as a number of people across the US are going back to some version of their normal lives.

That includes people in active treatment for cancers of the blood or for solid tumors, certain organ transplant and stem cell recipients, people with advanced or untreated HIV, and those who take high-dose corticosteroids or other drugs that may suppress their immune system.

A new study published by the CDC last week suggests people with compromised immune systems may need to receive three doses of a coronavirus vaccine and a booster shot to get as much protection afforded by two doses to those who are not immunocompromised. For transplant recipients like Linder and some other members of the immunocompromised community, the research showed that vaccine effectiveness was lower than that.

CNN followed up with five immunocompromised people interviewed in March Others have gotten a sense of security after getting vaccinations and booster shots. She said she received a booster in August and would consider a fourth dose if needed. Being vaccinated and boosted has also given Hodge the confidence to feel safe going to craft and vendor shows to to further the candy business she started during the pandemic.

Embracing life and trying to get back out into the world is also what Danielle Grijalva has tried to focus on, despite having a few people around her get sick and losing a friend to Covid, she said.

Grijalva received her first and second Covid shots in April and May, respectively, and she said being vaccinated changed her outlook, allowing her to shift from mostly staying at home to feeling safe enough to grocery shop or see friends.

The mother of two from California was diagnosed in with a pain condition called fibromyalgia, chronic fatigue syndrome and several strains of echoviruses, which were found in her stomach. She said she will be eligible for her booster shot this month. Regardless, she said she is happy to see things reopening in the US and is enjoying seeing good friends and feeling a little bit of normalcy again.

But not all the immunocompromised people CNN followed up with were able to stay healthy and Covid free. Brittania Powell, a student at The Ohio State University, barely left her home for two months last fall until her family encouraged her to come work the polls in Ohio on Election Day , she said. Powell was diagnosed with the autoimmune disease lupus when she was She also has an autoimmune disease called rheumatoid arthritis, anemia and lupus nephritis, which inflames her kidneys.

He spun fantastical tales of secret government missions. And when it all started to unravel, he ripped a page from a John Grisham thriller, leaving U. Marshal criminal profilers to make sense of a cryptic farewell note. A former employee of Ruffo's has come forward with a rare home video showing the wanted fugitive before he disappeared more than 20 years ago. Linda Lausten spent 19 years married to a man she never really knew.

His escape sent her reeling -- as if widowed by a husband who wasn't dead. She starts to uncover clues about who John Ruffo really was. As the U. Marshals continue their search, go along as a tantalizing lead takes them inside Dodger Stadium. Investigators thought they knew John Ruffo when they exposed his crime.

But in tape recorded prison calls, Ruffo's accomplice tells the FBI they don't know the half of it. One of Ruffo's lawyers reveals the reason he needed a top secret clearance to mount Ruffo's defense. And as Ruffo's past takes shape, U. Marshals enter a maze of fake identities and front companies, trying to follow the money. In secret diaries he left behind, John Ruffo spins an exotic Cold War tale.

But is it all part of another Ruffo con? Did one FBI veteran carry crucial information to the grave? Marshals head to Rome for answers in the midst of a global pandemic.

They try and rekindle the search for the fugitive on the Adriatic coast.